Warning and Precaution
Potential for Incorrect Blood Glucose Reading
Patients receiving EXTRANEAL (icodextrin) for peritoneal dialysis therapy may have incorrect blood glucose results when using particular blood glucose monitoring systems.
ONLY use glucose-specific monitors and test strips. These methods are common in clinical laboratories.
The term “glucose-specific” applies to monitors or test strips that are not affected by the presence of maltose or certain other sugars. Because EXTRANEAL (icodextrin) peritoneal dialysis solution results in elevated blood levels of maltose, only glucose-specific monitors and test strips should be used. Glucose-specific monitors and test strips include glucose oxidase (GOD), hexokinase, glucose dehydrogenase with nicotinamide adenine dinucleotide (GDH-NAD), or glucose dehydrogenase with flavin-adenine dinucleotide (GDH-FAD) based methods.
DO NOT use monitors or test strips that utilize the enzyme glucose dehydrogenase pyrroloquinolinequinone (GDH-PQQ) or glucose-dye-oxidoreductase. If GDH-PQQ-based or glucose-dye-oxidoreductase-based methods are used, using EXTRANEAL may cause a falsely high glucose reading, which could result in the administration of more insulin than needed. This can cause hypoglycemia, which can result in loss of consciousness, coma, neurological damage and death. Additionally, falsely elevated blood glucose measurements due to maltose interference may mask true hypoglycemia and allow it to go untreated with similar consequences.
To determine what type of method is used for monitoring glucose levels, review the labeling for BOTH the glucose monitor and the test strips used. If in doubt, contact the manufacturer of the glucose monitors and test strips to determine the specific type of testing that is used.
For important information about EXTRANEAL (icodextrin) or glucose monitors and test strips , including glucose monitor company contact information, please see the information in the links below.
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Important Safety Information | |
Additional Information |
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